Study of antipyretic therapy in current use

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Study of antipyretic therapy in current use 315

67 children aged between 6 months and 5 years presenting to the casualty department of the Royal Children's Hospital with a fever greater than 39 5 °C rectally (39 0 'C orally) were studied. Patients were excluded if either gastroenteritis or dehydration was present, or if antibiotics were considered necessary at the time of the study. 9 children were excluded for failing to achieve a response ...

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Fever is among the most common manifestations of disease and antipyresis is one of the most usual therapeutic intervention undertaken. A variety of microbial products including endotoxins and exotoxins are recognized as exogenous pyrogens which induce host cells to produce mediators known as endogenous pyrogens. The best studied endogenous pyrogen is interleukin 1, others include tumor necrosis...

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Brief history of antipyretic therapy.

Both external cooling and pharmacotherapy have been used to treat fever since time immemorial. In the past century such treatments have proliferated at an astonishing rate. The COX-2 inhibitors are the most recent additions to the antipyretic pharmacopoeia. Additional research is needed to determine whether they represent an important new chapter in antipyretic therapy's long history or, for th...

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Antipyretic therapy in patients with sepsis.

Sepsis is a clinical syndrome characterized by a systemic inflammatory response to infection. Mortality rates in sepsis have remained high, despite recent advances in our understanding of the immunological mechanisms that cause sepsis. Fever, a nonspecific acute-phase response, has been associated with improved survival and shortened disease duration in some infections. This article reviews the...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1973

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.48.4.313